Anti-SREBF2 Antibody

Raised in rabbit against the SREBF2 protein, this polyclonal IgG reagent from Antibodies.com targets SREBP-2, the basic-helix-loop-helix-leucine zipper transcription factor that governs cholesterol biosynthesis and LDL receptor gene expression. Supplied unconjugated in a 200 µL vial, the antibody is validated for immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue sections and shows reactivity across human, mouse, and rat samples. Because the polyclonal preparation binds multiple epitopes, both the membrane-tethered precursor and the cleaved, nuclear-localized mature form of SREBP-2 can be detected, which is useful for tracking proteolytic activation. Researchers mapping sterol regulatory pathways, lipid metabolism, or statin response in normal and disease tissues can apply the antibody to compare expression patterns between species and tissue types. For short-term use, store at 4 °C; aliquoting extends stability across repeated freeze-thaw cycles and helps preserve titer over the lifetime of the vial.