Anti-SQSTM1 Antibody

The antibody recognizes SQSTM1, also called p62, a scaffold and cargo receptor that links ubiquitinated substrates to selective autophagy machinery and the proteasome. Beyond its canonical role in autophagic flux, p62 sits at the intersection of Nrf2-driven antioxidant responses and mTORC1 nutrient signaling, and it is one of the most commonly used readouts for protein aggregate clearance in neurodegeneration research, where p62-positive inclusions are tracked in ALS, frontotemporal dementia, and Parkinson disease models. Tumor biology groups also follow SQSTM1 levels as an indicator of cellular stress and transformation.

From Antibodies.com, this unconjugated mouse IgG1 monoclonal reagent is supplied as 100 µl in a vial in 1% BSA, 40% glycerol, TBS (pH 7.4) with 0.05% sodium azide as preservative, and is validated for Western blot, immunocytochemistry, immunohistochemistry, and flow cytometry on human, mouse, and rat samples.