Anti-SPTLC1 Antibody

The antibody targets SPTLC1 (Serine Palmitoyltransferase Long Chain Subunit 1), the catalytic core of the serine palmitoyltransferase complex that catalyzes the condensation of L-serine with palmitoyl-CoA, the rate-limiting first step in de novo sphingolipid biosynthesis. This rabbit polyclonal reagent from Antibodies.com is unconjugated and validated for Western blot and immunohistochemistry on human samples, supporting studies of sphingolipid metabolism, ER membrane biology, and the molecular pathology of hereditary sensory neuropathy type 1 (HSAN1), where dominant SPTLC1 mutations alter substrate specificity. Supplied as 100 µl of polyclonal antiserum, the antibody enables detection of endogenous SPTLC1 in cell lysates and formalin-fixed tissue sections, fitting workflows in lipid metabolism research, neurobiology, and membrane biochemistry.