Anti-SPINT2 Antibody

SPINT2 (Serine Protease Inhibitor, Kunitz Type 2), also referred to as HAI-2, is a Kunitz-type transmembrane serine protease inhibitor that restrains the activity of hepatocyte growth factor activator (HGFA), matriptase, and prostasin in epithelial tissues. Antibodies.com supplies a 100 µl aliquot of unconjugated rabbit polyclonal antibody raised against this target, with documented applications in Western blot (WB) and immunofluorescence (IF) on human samples.

The reagent is used to study serine protease network regulation, with relevance to epithelial physiology, sodium channel biology, and conditions linked to SPINT2 loss-of-function variants such as congenital tufting enteropathy. Investigators also apply this antibody to characterize protease-dependent growth factor activation in hepatocyte and placental tissue models. The polyclonal format offers recognition of multiple epitopes, supporting detection across lysate-based and cell-based assays when paired with appropriate secondary reagents.

For handling, aliquot upon receipt, store at -20°C in a manual defrost freezer, protect from light, and limit freeze-thaw cycles to preserve antibody performance across experiments.