Anti-SPHK2 Antibody

Sphingosine kinase 2 (SPHK2) catalyzes the ATP-dependent phosphorylation of sphingosine to generate sphingosine-1-phosphate, a lipid signaling molecule implicated in cell survival, proliferation, inflammatory responses, and immune cell trafficking. This rabbit polyclonal antibody from Antibodies.com targets SPHK2 and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows. The unconjugated reagent is supplied as a 100 µl volume and detects both human and mouse SPHK2, supporting cross-species studies in cancer biology, metabolic research, and investigations of the sphingolipid pathway. The antibody pairs well with standard chromogenic or fluorescent detection systems in IHC and with chemiluminescent or colorimetric Western blot protocols, enabling researchers to monitor SPHK2 expression across cultured cells and tissue specimens. As a polyclonal reagent, it recognizes multiple epitopes on SPHK2, which can improve tolerance to minor conformational variation between species orthologs and across experimental conditions.