Anti-SPCS2 Antibody

The SPCS2 target (Signal Peptide Complex Subunit 2, also known as microsomal signal peptidase subunit 25 kDa) is one of the integral membrane components of the endoplasmic reticulum signal peptidase complex that cleaves N-terminal signal peptides from nascent secretory and membrane proteins during co-translational translocation. This polyclonal reagent from Antibodies.com is raised in rabbit and validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human samples, supplied as 100 µl of unconjugated antiserum ready for direct labeling or secondary-detection conjugation. Researchers studying protein translocation, ER-Golgi trafficking, secretory pathway function, viral polyprotein processing, and membrane protein biogenesis use SPCS2 immunolabeling to monitor complex integrity, map subcellular localization in fixed tissue sections, and confirm expression in cell lysates.

SPCS2 functions as part of the heterotetrameric SPC (SPCS1/SPCS2/SPCS3/SEC11) signal peptidase complex, and altered expression has been linked to changes in secretory throughput across several cellular models. For optimal stability, the antiserum should be stored refrigerated for short-term use and aliquoted and frozen at -20°C for long-term preservation of activity. Intended for research use only.