Anti-SPATA6 Antibody

This rabbit polyclonal antibody targets SPATA6 (Spermatogenesis Associated Protein 6), a testis-enriched cytoskeletal scaffold essential for manchette organization and sperm head shaping during spermiogenesis. Raised in rabbit and supplied as an unconjugated IgG preparation at 100 µL, the reagent is validated by Antibodies.com for Western blot and immunohistochemistry on human samples, supporting detection of endogenous SPATA6 in fixed tissue sections and detergent-solubilized lysates. Published loss-of-function studies in mouse models link SPATA6 deficiency to globozoospermia and male infertility, so reliable immunolabeling of the protein in human reproductive tissues and cultured spermatogenic cells is useful for andrology, reproductive biology, and infertility research. The polyclonal format increases the likelihood of recognition across multiple epitopes of the SPATA6 antigen, which can be advantageous when probing samples in which post-translational modification or species variation may affect a single-epitope reagent. For routine use, aliquot the antibody and store at -20 °C, protecting the vial from repeated freeze-thaw cycles to preserve binding activity over the working shelf life.