Anti-SPATA18 Antibody

This rabbit polyclonal antibody targets SPATA18 (Spermatogenesis Associated 18), a mitochondria-associated protein also known as MIEAP (Mitochondria-Eating Protein) that drives clearance of dysfunctional mitochondria through a lysosome-dependent quality-control pathway. The antibody is unconjugated and supplied as 100 µl of ready-to-use reagent, raised in rabbit and validated for western blot (WB) and immunohistochemistry (IHC) on human samples. SPATA18 expression has been studied in the context of mitochondrial homeostasis, oxidative stress response, and tumor biology, where its loss has been linked to accumulation of defective mitochondria in gastric cancer and other malignancies. Recommended storage is at -20 °C for long-term stability, with working aliquots stored refrigerated and protected from repeated freeze-thaw cycles. The polyclonal mixture targets multiple epitopes across the SPATA18 sequence, which improves signal robustness in IHC where antigen masking can occur in fixed tissue sections. For western blot, the antibody is applied to lysates from human cell lines or tissue homogenates, producing bands consistent with the predicted molecular weight of the SPATA18/MIEAP protein. Researchers investigating mitochondrial turnover, mitophagy, spermatogenesis-related disorders, and cancer cell metabolism use this reagent as part of their experimental workflow. Provided by Antibodies.com as a primary antibody intended for research use only.