Anti-SPARC Antibody

Secreted Protein Acidic and Rich in Cysteine (SPARC), also referred to as osteonectin or BM-40, is a matricellular glycoprotein that regulates cell-matrix interactions and extracellular matrix assembly. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against human SPARC and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, supporting detection of endogenous SPARC expression across cell lysates, tumor xenografts, and formalin-fixed tissue sections. Supplied as 100 µl of polyclonal antiserum in a single vial, the reagent is widely applied in studies of tumor microenvironment biology, fibrotic tissue remodeling, wound healing, and bone formation. Researchers commonly use it to profile SPARC expression in melanoma, glioma, breast carcinoma, and colorectal cancer models, where altered SPARC levels have been linked to disease progression, metastatic behavior, and response to therapy.