Anti-SOS2 Antibody

This rabbit polyclonal antibody from Antibodies.com targets SOS2 (Son of Sevenless 2), a Ras-specific guanine nucleotide exchange factor that couples receptor tyrosine kinase activation to Ras-MAPK signaling cascades. The reagent is provided as a 100 µl liquid preparation at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide, pH approximately 7.2, and is supplied unconjugated for maximum flexibility in downstream assay design.

Validated for Western blot (WB) and immunocytochemistry (ICC), the antibody detects endogenous SOS2 in human, mouse, and rat samples, supporting cross-species studies of growth factor signaling, including EGF- and PDGF-driven Ras activation, neuronal differentiation pathways, and cancer cell models where aberrant Ras-MAPK output is of interest. As a polyclonal reagent, it recognizes multiple epitopes on the SOS2 protein, which is helpful for detecting the target in samples where post-translational modification may mask individual binding sites.

For best stability, the vial should be refrigerated between uses; aliquoting is recommended to limit freeze-thaw cycles if stored at -20°C for long-term use. Sodium azide is included as a preservative, and the solution is ready to use at working dilutions appropriate for immunoblotting and immunostaining protocols.