Anti-SOCS3 Antibody

SOCS3 (Suppressor of Cytokine Signaling 3) is a critical negative feedback regulator of the JAK/STAT cytokine signaling cascade. The Anti-SOCS3 Antibody from Antibodies.com is a polyclonal reagent validated for detecting this approximately 30 kDa intracellular protein across human, mouse, and rat sample types.

Validated uses and key features:

• Applications: Western blot and immunohistochemistry
• Reactivity: Human, Mouse, Rat
• Host species: Rabbit; Clonality: Polyclonal for multi-epitope recognition
• Conjugate: Unconjugated, compatible with custom secondary antibody workflows
• Format: 100 µl aliquot supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol
• Storage: Store frozen at -20 °C; the glycerol cryoprotectant limits freeze-thaw damage

SOCS3 induction is a hallmark of cytokine-driven JAK/STAT activation, and researchers investigating IL-6 signaling, leptin resistance, hepatic inflammation, or tumor microenvironment feedback loops routinely monitor endogenous SOCS3 levels. The unconjugated format also supports downstream flexibility, including custom fluorescent or enzymatic labeling for co-localization studies in fixed tissue.