Anti-SOCS1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets SOCS1 (Suppressor of Cytokine Signaling 1), a critical negative regulator of the JAK/STAT signaling cascade. SOCS1 functions within an inducible feedback loop that attenuates cytokine-driven signal transduction, making it a focal target in studies of immune cell differentiation, inflammatory responses, and tumor suppressor biology.

Validated for Western blot (WB) and immunohistochemistry (IHC), the reagent reacts with human, mouse, and rat samples, supporting cross-species experimental work in immunology, oncology, and cell signaling research. Each vial contains 100 µl of unconjugated antibody, suitable for chromogenic IHC staining and standard immunoblotting protocols.

Researchers commonly use this antibody to investigate SOCS1 induction by interferons and interleukins, its frequent silencing in lymphoma and hepatocellular carcinoma models, and its role in modulating T helper cell polarization. It is also applied to probe crosstalk between cytokine pathways and insulin or growth factor signaling networks.