Anti-SOCS-3 Antibody

SOCS-3 (suppressor of cytokine signaling 3) is a feedback inhibitor of the JAK-STAT pathway, and this rabbit polyclonal reagent from Antibodies.com offers a primary antibody tool for its detection. The unconjugated antibody is supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, in a 100 µl vial intended for western blot workflows.

SOCS-3 expression is commonly examined in studies of cytokine-driven inflammation, leptin and insulin signaling, and immune cell regulation. The antibody is listed for reactivity with human, mouse, and rat samples, supporting cross-species comparison in cell lysates and tissue homogenates. Researchers in metabolism, immunology, and oncology use SOCS-3 detection to investigate the negative feedback loops that limit JAK-mediated signal transduction.

For best results, dilute in blocking buffer according to your established WB protocol and incubate with transferred membranes prior to chemiluminescent or chromogenic detection. The polyclonal format yields recognition of multiple epitopes on the SOCS-3 target, supporting consistent signal in heterologous expression systems and endogenous samples.