Anti-SNW1 Antibody

Raised in rabbit against SNW1 (also called SKIP, NCOA-62, or PRPF45), this polyclonal IgG reagent from Antibodies.com targets a 62 kDa nuclear protein that couples pre-mRNA splicing to transcriptional regulation. The unconjugated antibody is supplied as 100 µl per vial in an affinity-purified format and has been validated for Western blot and immunofluorescence on human and mouse samples. SNW1 functions both as a component of the U2 small nuclear ribonucleoprotein spliceosomal complex and as a coactivator for the vitamin D receptor, the Notch intracellular domain (RBP-Jκ), SMAD2/3, and NF-κB. The reagent supports work on spliceosome assembly, nuclear receptor crosstalk, and transcriptional elongation of inflammatory target genes. Documented research applications include probing SKIP association with VDR at vitamin D response elements, tracking splicing-dependent events in the DNA damage response, and examining cell cycle progression where SNW1 cooperates with Ski to overcome pRb-mediated arrest.