Anti-SNRPB Antibody

This polyclonal antibody from Antibodies.com targets SNRPB, the small nuclear ribonucleoprotein polypeptide B protein, which forms part of the Sm core of spliceosomal snRNPs and participates in pre-mRNA splicing. Raised in rabbit and affinity-purified, the reagent is supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol as a 100 µl aliquot, validated for immunoblotting and immunohistochemistry workflows on human, mouse, and rat samples.

The unconjugated format allows pairing with secondary reagents of the researcher's choice, including HRP, Alexa Fluor, and biotin conjugates. Tested applications include Western blot to detect the endogenous SNRPB band and immunohistochemistry on tissue sections for visualization of nuclear staining patterns characteristic of spliceosomal localization. Researchers studying RNA splicing, spliceosome assembly, and autoantibody responses to snRNP proteins—SNRPB is a known autoantigen in mixed connective tissue disease and systemic lupus erythematosus—will find this reagent valuable for profiling expression across model systems.

For best results, keep the antibody refrigerated in the supplied glycerol-containing buffer to preserve activity; aliquot if extended storage is needed, and avoid repeated freeze-thaw cycles. The vial format supports reproducible experimental setup across multiple blotting or staining runs.