Anti-SNRPA Antibody

For researchers studying pre-mRNA splicing and U1 snRNP biology, this Antibodies.com rabbit polyclonal antibody targets SNRPA (Small Nuclear Ribonucleoprotein Polypeptide A), the protein A component of the U1 small nuclear ribonucleoprotein particle. SNRPA participates in 5' splice site recognition during spliceosome assembly, and detecting this protein supports studies of RNA processing, nuclear speckle organization, and post-transcriptional gene regulation in mammalian systems.

The unconjugated reagent is validated for Western blot (WB) and immunofluorescence (IF) workflows and reacts with SNRPA in human, mouse, and rat samples, enabling comparative work across cell line panels, primary tissue lysates, and rodent model systems. The polyclonal host response provides epitope diversity that can improve signal recovery when target abundance is low or when investigating multiple SNRPA-containing complexes.

Each vial contains 100 µL of liquid antibody, sufficient for multiple blotting and imaging experiments. The unconjugated format allows pairing with a selection of secondary reporters, including HRP, Alexa Fluor, and biotin conjugates, depending on downstream detection chemistry. Standard refrigerated storage plus aliquoting is recommended to preserve activity across repeated freeze-thaw cycles.

Common applications include probing U1 snRNP integrity in nuclear extracts, monitoring changes in spliceosome composition during cellular differentiation or stress responses, and validating knockdown or knockout efficiency in CRISPR-edited cell lines. The antibody is offered under the Primary Antibodies category for research use only.