Anti-SnoN Antibody

SnoN, encoded by the SKIL gene, is a key transcriptional regulator within the TGF-beta/Smad signaling pathway that controls cell proliferation, senescence, and tumor progression. This rabbit polyclonal antibody recognizes endogenous SnoN protein and supports studies in human and mouse model systems where the role of SnoN in oncogenic transformation, growth arrest, and feedback inhibition of TGF-beta responses is under investigation.

Provided by Antibodies.com as an unconjugated polyclonal reagent in a 100 µl format, the antibody is validated for Western blot, immunohistochemistry, and ELISA workflows. Its unconjugated format allows researchers to pair it with HRP, biotin, or fluorophore-conjugated secondary reagents depending on experimental needs. The polyclonal nature of the reagent enables recognition of multiple epitopes on SnoN, which can be advantageous when studying protein expression across different tissue contexts or when monitoring changes in SnoN levels under varying cellular conditions.

Key features

• Target: SnoN (SKIL proto-oncoprotein), a Smad-binding transcriptional co-repressor
• Host species: Rabbit; clonality: Polyclonal
• Conjugate: Unconjugated for flexible secondary detection
• Reactivity: Human and mouse
• Validated applications: WB, IHC, ELISA
• Format: 100 µl liquid aliquot

Recommended applications

Western blot detection of SnoN in whole-cell lysates from human or mouse cell lines, immunohistochemistry on paraffin-embedded tissue sections to map SnoN nuclear localization in tumor or developmental samples, and ELISA-based quantification when paired with appropriate matched secondary antibodies. Refrigerate upon arrival and aliquot to preserve activity across multiple experiments.