Anti-SNCB Antibody

This rabbit polyclonal reagent from Antibodies.com specifically recognizes beta-synuclein (SNCB), a 14 kDa presynaptic protein abundantly expressed in central nervous system tissue. Supplied as a 200 µl vial of unconjugated IgG, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) applications on human and mouse specimens. Beta-synuclein belongs to the synuclein family alongside alpha- and gamma-synuclein, and it has attracted research interest for its putative neuroprotective role in neurodegenerative disease, including Parkinson's disease, dementia with Lewy bodies, and other synucleinopathies. Investigators use anti-SNCB antibodies to probe aggregation dynamics, compare expression patterns between healthy and diseased brain tissue, and characterize the interplay between beta- and alpha-synuclein in dopaminergic neurons. The polyclonal clonality enables recognition of multiple epitopes, supporting detection of isoforms or post-translational modifications. In Western blot, the antibody detects the expected band in brain lysates, and in IHC it permits cellular localization studies in fixed sections from rodent models and human neuropathology samples.