Anti-SNCA (phospho Y125) Antibody - Identical to Abcam (ab194771)

The antibody recognizes alpha-synuclein (SNCA) phosphorylated at tyrosine 125, a post-translational mark associated with early pathogenic oligomer formation and Lewy body pathology in Parkinson's disease research. Phosphorylation at Y125 has been reported to influence membrane binding and aggregation kinetics of alpha-synuclein, making site-specific phospho-antibodies useful for tracking modified species in neuronal cell and tissue models.

This Antibodies.com reagent is a rabbit polyclonal IgG, supplied unconjugated at 200 µl per vial, and validated for Western blot (WB) and immunofluorescence (IF) workflows on human and mouse samples. The antibody matches the specificity of Abcam ab194771 and reacts with the phosphorylated Y125 epitope, allowing researchers to probe tyrosine-phosphorylated alpha-synuclein in transfected cell lines, primary neuron cultures, and synucleinopathy-relevant tissue lysates. Store aliquoted at -20 °C and avoid repeated freeze-thaw cycles to preserve phospho-specific binding activity across multiple experiments.