Anti-SNCA Antibody

Raised against alpha-synuclein, the 140-amino acid presynaptic protein whose aggregation into Lewy bodies defines Parkinson's disease and related synucleinopathies, this rabbit polyclonal reagent from Antibodies.com is supplied in a single-use vial as 100 µl of unconjugated IgG at 1 mg/ml in phosphate-buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.3. Validated for Western blot detection of endogenous SNCA in human, mouse, and rat samples, the antibody supports studies of protein aggregation, mitochondrial dysfunction, and neurodegeneration mechanisms in dopaminergic neuron cultures, transgenic rodent models, and brain tissue lysates. The polyclonal format increases the likelihood of recognizing multiple epitopes on full-length and truncated synuclein species, including phosphorylated serine 129 forms used as markers of pathological inclusions. For long-term storage, aliquot the antibody and freeze at -20°C to minimize freeze-thaw cycles and preserve binding activity, and protect from light when handling the working solution.