Anti-SNCA Antibody

Alpha-synuclein, encoded by the SNCA gene, is a 140 amino acid presynaptic protein central to Parkinson's disease research and related synucleinopathies, where it aggregates to form the core of Lewy body inclusions in affected neurons. This rabbit polyclonal IgG reagent from Antibodies.com targets the human SNCA protein and is supplied as an unconjugated 200 µl volume, giving laboratories flexibility for downstream labeling with their preferred secondary detection reagents, including HRP conjugates, fluorophores, or biotin-based systems.

The polyclonal format enables recognition of multiple epitopes across the alpha-synuclein sequence, supporting detection of both full-length protein and post-translationally modified species generated under pathological conditions. Validated applications cover Western blot for protein-level verification, immunohistochemistry for spatial localization in patient-derived or model tissue sections, and flow cytometry for single-cell analyses. Cross-reactivity with human, mouse, and rat samples permits parallel experiments across patient specimens and transgenic rodent models of synucleinopathy.

For handling, store at 4°C for short-term use, and aliquot upon arrival for long-term storage at -20°C to limit freeze-thaw damage and preserve reagent activity across repeated experiments.