Anti-SNAP25 Antibody

SNAP25 (Synaptosomal-Associated Protein, 25 kDa) is a presynaptic SNARE complex component that docks synaptic vesicles to the plasma membrane and drives calcium-triggered neurotransmitter release. Antibodies.com provides this rabbit polyclonal antiserum as a 100 µl unconjugated preparation validated for Western blot and immunohistochemistry on human, mouse, and rat specimens. In neuronal lysates the reagent labels a discrete band near 25 kDa, and on fixed tissue sections it selectively decorates presynaptic boutons, supporting studies of synapse formation, synaptic plasticity, and neurodegenerative disease models. Because SNAP25 is the proteolytic substrate of botulinum neurotoxins type A and E, the reagent is also widely used in exocytosis and toxin-cleavage assays. For best results, aliquot on arrival and store at -20 °C, avoiding repeated freeze-thaw cycles of the working stock.