Anti-SMYD2 Antibody

This polyclonal antibody from Antibodies.com targets SMYD2, a SET and MYND domain-containing lysine methyltransferase that catalyzes methylation of histone H3 at lysine 36 and several non-histone substrates including p53, RB1, ERα, and HSP90. Raised in rabbit and supplied as an unconjugated whole antiserum at 100 µl per vial, the reagent is validated for Western blot and immunofluorescence workflows across human, mouse, and rat samples, supporting studies of chromatin regulation, transcription, and DNA damage response pathways where SMYD2 activity has been implicated.

For handling, aliquot upon first thaw to limit freeze-thaw cycles and store the antibody frozen at -20°C, avoiding repeated temperature shifts that can reduce titer in polyclonal preparations. The unconjugated format gives flexibility to conjugate the antibody to HRP, fluorophores, or biotin in-house, and the polyclonal nature provides broader epitope coverage useful when probing full-length SMYD2 or detecting lower-abundance methyltransferase isoforms. Researchers investigating cardiac development, oncogenic signaling, or steroid receptor biology frequently deploy this reagent to track endogenous SMYD2 levels in cell lysates and fixed tissue sections. For research use only.