Anti-SMO Antibody

The Smoothened (SMO) protein is a seven-transmembrane G protein-coupled receptor that operates within the Hedgehog (Hh) signaling cascade, transducing signals from the Patched receptor to GLI transcription factors during embryonic patterning and adult tissue homeostasis. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against SMO and has been validated for Western Blotting (WB) and Immunohistochemistry (IHC) on human, mouse, and rat samples.

The antibody is supplied as a 200 µl liquid vial and supports research into Hedgehog pathway regulation, primary cilium biology, and SMO-driven oncogenesis in basal cell carcinoma and medulloblastoma. Its polyclonal IgG format enables recognition of multiple epitopes on the SMO protein, which can be useful when probing native receptor expression across varied tissue preparations, whole-cell lysates, and fixed sections.