Anti-SMG7 Antibody

This rabbit polyclonal antibody from Antibodies.com targets SMG7, a key component of the nonsense-mediated mRNA decay (NMD) pathway that safeguards transcriptome integrity by eliminating transcripts containing premature termination codons. SMG7 functions within the SMG1 complex alongside SMG5 and SMG6, contributing to the phosphorylation cycle of UPF1 and the recruitment of decay machinery to aberrant mRNAs. Beyond canonical NMD, SMG7 has been implicated in stress granule assembly, telomere maintenance, and the regulation of select long 3'UTR transcripts in human cells.

The reagent is supplied as 100 µl of unconjugated antiserum for Western blot (WB) and immunofluorescence (IF) workflows. Raised in rabbit, this polyclonal reagent recognizes human SMG7 and provides flexibility for detection across multiple experimental platforms without the constraints of a pre-conjugated reporter. Researchers investigating mRNA quality control, gene expression regulation, or the cellular response to translation-termination errors will find this antibody a useful tool for probing endogenous SMG7 distribution and abundance.