Anti-SMG6 Antibody

Raised in rabbit against the SMG6 nonsense-mediated mRNA decay factor, this unconjugated polyclonal IgG reagent from Antibodies.com is supplied as a 50 µl liquid vial and validated for Western blot detection of the ~160 kDa endonuclease in human and rat samples. SMG6 (also annotated as C17orf31, EST1A, KIAA0732, or telomerase-binding protein EST1A) executes the endonucleolytic cleavage step inside the SMG1-UPF1-UPF2-UPF3 (SURF) complex on the ribosome, initiating rapid degradation of aberrant transcripts bearing premature termination codons. Affinity-purified and shipped as a ready-to-use liquid formulation, the reagent is stored at -20°C and handled under conditions that avoid repeated freeze-thaw cycles. Researchers investigating nonsense-mediated decay, post-transcriptional gene regulation, stress responses, telomere maintenance, or embryonic development apply this reagent to probe SMG6 expression and dissect SURF complex assembly across the validated human and rat reactivity profile.