Anti-SMG6 Antibody

SMG6 is the catalytic endonuclease that performs cleavage of transcripts bearing premature termination codons during nonsense-mediated mRNA decay (NMD), the eukaryotic quality-control pathway that suppresses defective mRNAs.

This polyclonal primary antibody from Antibodies.com is raised in rabbit, isotype IgG, and unconjugated for flexible detection chemistry. It is supplied as 100 µl of liquid and validated for western blot analysis of endogenous SMG6 expression in human and rat cell and tissue lysates.

The reagent is recommended for research use only, supporting investigations into NMD factor composition (for example, the SURF complex with SMG1, UPF1, and UPF2), telomere maintenance functions of SMG6, and stress-response reprogramming of mRNA turnover. It is paired with standard HRP-conjugated anti-rabbit secondaries for chemiluminescent or chromogenic western blot imaging under denaturing SDS-PAGE conditions.