Anti-SMC6 Antibody

This rabbit polyclonal antibody recognizes human SMC6 (Structural Maintenance of Chromosomes protein 6), a core subunit of the SMC5/6 complex that safeguards genome stability through DNA double-strand break repair, homologous recombination, and replication fork protection. Supplied by Antibodies.com as an unconjugated reagent in a 100 µl volume, the antibody is validated for Western blot and immunohistochemistry workflows. It detects the endogenous SMC6 polypeptide in human samples, supporting studies of the DNA damage response, chromatin organization, and mitotic chromosome architecture. The polyclonal format yields recognition of multiple epitopes on the target, useful when probing conformational variants or post-translationally modified forms of SMC6. Researchers apply this reagent to investigate SMC5/6 complex localization at nuclear foci that form after genotoxic stress, as well as its roles in resolving replication stress and in homologous recombination pathways. The unconjugated format allows flexible choice of secondary detection reagents, including HRP, fluorophore, or biotin conjugates, depending on the downstream assay. For immunoblotting, the antibody can be paired with standard chemiluminescent or fluorescent detection systems, while on tissue sections it supports chromogenic or immunofluorescence visualization of SMC6 distribution in human specimens.