Anti-SMC1B Antibody

The Anti-SMC1B polyclonal antibody from Antibodies.com targets the Structural Maintenance of Chromosomes 1B protein, a meiosis-specific subunit of the cohesin ring complex. This rabbit polyclonal reagent is supplied as 100 µl of unconjugated antiserum, validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples. SMC1B loads onto chromatin during early meiotic prophase I and supports homologous recombination by stabilizing recombination intermediates and enforcing sister chromatid cohesion until anaphase I. Loss-of-function studies in murine models have shown that SMC1B deficiency triggers premature separation of sister chromatids, aberrant DNA double-strand break repair, and arrest at a pachytene-like stage, while human genetic studies link coding variants to premature ovarian insufficiency and recurrent pregnancy loss, making this antibody a useful reagent for reproductive biology, germ cell development, and DNA repair research. The unconjugated format allows downstream flexibility, since HRP-, biotin-, or fluorophore-conjugated secondary antibodies can be paired for detection across WB, IHC, and IF platforms. Storage at -20 °C in working aliquots is recommended to preserve activity across multiple freeze-thaw cycles for ongoing meiosis and chromosome dynamics studies.