Anti-SMC1A (N-term) Antibody

Produced by Antibodies.com as a mouse monoclonal IgG1 reagent, this unconjugated antibody recognizes the N-terminal region of Structural Maintenance of Chromosomes 1A (SMC1A), a core subunit of the cohesin complex that holds sister chromatids together after replication and is essential for accurate chromosome partitioning during mitosis, homologous recombination-based DNA repair, and the regulation of chromatin loop extrusion and gene expression. Validated for Western blot, immunohistochemistry, and flow cytometry, the purified reagent is supplied at 100 µL per vial and has been tested for reactivity against human, mouse, and rat samples, making it applicable to comparative studies in cell line panels, primary tissue sections, and suspension or adherent cell preparations. Researchers use this anti-SMC1A antibody to monitor cohesin loading on chromatin, to assess phosphorylation-dependent signaling following DNA damage, to explore the role of cohesinopathy mutations in Cornelia de Lange syndrome and related developmental disorders, and to verify engineered knockout or knockdown models in basic and translational research laboratories.