Anti-SMC1A Antibody

SMC1A (Structural Maintenance of Chromosomes 1A) is a core subunit of the cohesin ring complex that tethers newly replicated sister chromatids from S phase through metaphase and is also recruited to DNA double-strand break sites for homology-directed repair. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against the human protein and validated for Western blot and immunohistochemistry workflows, supporting studies of cell-cycle checkpoint activation, ATM/ATR-dependent phosphorylation events, and chromatin organization in human-derived samples. The antibody is supplied as 100 µl of polyclonal antiserum and is reactive with human SMC1A, making it a useful tool for laboratories investigating Cornelia de Lange syndrome, cohesinopathies, and the DNA damage response pathways implicated in tumor biology.