Anti-SMC1 (Ab-957) Antibody

Antibodies.com offers this rabbit polyclonal antibody raised against the phosphorylated form of Structural Maintenance of Chromosomes 1 (SMC1) at serine 957, a site modified by ATM kinase as part of the cellular DNA damage response. The reagent is supplied unconjugated in a 100 µL volume and is validated for Western blot and immunohistochemistry on human samples. Common applications include studies of double-strand break signaling, ATM/ATR pathway activation, and S-phase checkpoint control. Laboratories investigating cohesin dynamics, genotoxic stress, or the molecular basis of radiosensitivity in cancer cell lines apply phospho-specific antibodies at this epitope to monitor rapid kinase-dependent phosphorylation events following irradiation or chemical DNA damage. Storage at -20°C in small aliquots preserves activity across multiple freeze-thaw cycles, and the polyclonal format improves tolerance for minor variation in surrounding sequence context compared with monoclonal alternatives.