Anti-SMARCB1 Antibody

The SMARCB1 protein (also known as INI1, BAF47, or SNF5) is a core subunit of the SWI/SNF ATP-dependent chromatin remodeling complex and functions as a tumor suppressor. Loss of nuclear SMARCB1 expression is the defining molecular hallmark of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors (AT/RT), and it is also frequently observed in epithelioid sarcoma and renal medullary carcinoma. This unconjugated rabbit polyclonal antibody from Antibodies.com targets human SMARCB1 and is validated for Western blot and immunohistochemistry applications, where it serves as a critical diagnostic reagent in surgical pathology for distinguishing SMARCB1-deficient neoplasms from histologic mimics. The antibody is supplied as 100 µl of polyclonal antiserum raised in rabbit and is intended for research use only in studies of chromatin remodeling, cancer biology, and tumor suppressor function.