Anti-SMARCB1 Antibody

This polyclonal reagent from Antibodies.com targets SMARCB1, a core subunit of the SWI/SNF ATP-dependent chromatin remodeling complex that acts as a tumor suppressor. Raised in Rabbit, the unconjugated antibody recognizes human, mouse, and rat SMARCB1, supporting cross-species use in chromatin biology and cancer research workflows.

Validated applications include Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation, enabling detection across fixed tissue sections, native protein extracts, and ChIP-grade chromatin preparations. Loss of SMARCB1 is a defining molecular feature of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumors, and this reagent is commonly referenced in studies investigating INI1/BAF47 status in tumor diagnostics.

The 100 µl format provides working volume for multiple staining and blotting experiments, with aliquot-based handling recommended to limit freeze-thaw cycles and preserve antigen-binding activity during long-term frozen storage.