Anti-SMARCA4 (R1614) Antibody

This rabbit polyclonal antibody targets SMARCA4, the ATPase catalytic subunit (also called BRG1) of the SWI/SNF chromatin-remodeling complex that reorganizes nucleosome structure to regulate transcription, DNA repair, and cell-cycle progression. From Antibodies.com, the reagent is supplied at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, and is validated for immunohistochemistry on formalin-fixed paraffin-embedded tissue sections. The unconjugated Ig preparation is raised in rabbit and binds the R1614 epitope region, supporting detection in human, mouse, and rat samples, which makes it useful for comparative studies of BRG1 expression across model organisms and tumor specimens where SMARCA4 loss is a recognized diagnostic feature (e.g., rhabdoid tumors, small cell carcinoma of the ovary, and certain non-small cell lung cancers). Each vial contains 100 µl of working stock; for short-term use, refrigerate in the dark to preserve activity, and avoid repeated freeze-thaw cycles by aliquoting upon first thaw.