Anti-SMAD7 Antibody

Raised in rabbit against the inhibitory SMAD family member SMAD7, this unconjugated polyclonal antibody from Antibodies.com supports researchers investigating TGF-beta superfamily signaling and its negative-feedback regulation in mammalian cells and tissues.

Validated for Western blot (WB) and immunohistochemistry (IHC), the reagent detects endogenous SMAD7 in samples from Human, Mouse, and Rat, making it applicable across comparative studies and translational workflows that span rodent models and human-derived material. The polyclonal format increases the chance of capturing multiple epitopes on the target, useful when expression levels are low or when probing for isoform-level differences within SMAD family members.

Each vial contains 100 µl of antibody, sufficient for multiple blotting or staining rounds. For best results, aliquot upon arrival, store refrigerated, and minimize freeze-thaw cycles. The reagent fits studies in fibrosis, cancer biology, inflammation, and BMP/activin/TGF-beta pathway analysis, where SMAD7 function as an intracellular antagonist of receptor signaling is the mechanistic question under investigation.