Anti-SMAD5 (C-term) Antibody

SMAD5 (Mothers Against Decapentaplegic Homolog 5) is a receptor-regulated SMAD protein central to BMP signaling, where it conveys signals from bone morphogenetic protein receptors to the nucleus to regulate gene transcription. This unconjugated mouse monoclonal IgG1 reagent from Antibodies.com binds the C-terminal region of SMAD5 and supports detection across multiple experimental platforms, including Western blot, immunocytochemistry, and flow cytometry. The antibody reacts specifically with SMAD5 from human, rat, and mouse samples, making it applicable to a wide variety of cell and tissue models used in developmental biology, osteogenesis, and iron homeostasis research. Supplied as 100 µl in a single vial, the antibody is used in studies of BMP-driven processes such as chondrogenesis, vascular remodeling, and hepcidin regulation, where phosphorylation of the C-terminal SSXS motif serves as a key readout of pathway activation. Storage recommendations follow standard liquid monoclonal handling: refrigerate the vial to maintain binding activity and limit freeze-thaw cycles.