Anti-SMAD3 Antibody

SMAD3 functions as a receptor-regulated transcription factor that conveys TGF-β signals from the cell surface into the nucleus, partnering with SMAD4 to drive expression of genes involved in epithelial-mesenchymal transition, extracellular matrix deposition, and tissue fibrosis. This rabbit polyclonal antibody from Antibodies.com was raised against the human SMAD3 protein and is validated for western blot and immunohistochemistry. Supplied as 100 µl of unconjugated antiserum, it recognizes the SMAD3 target in human, mouse, and rat samples, giving researchers a flexible reagent for studies of TGF-β pathway activation across vertebrate model systems. Upon receipt, aliquot the antiserum and store at -20 °C, minimizing freeze-thaw cycles to maintain titer over the working life of the product.