Anti-SMAD2 (phospho T220) Antibody

SMAD2 is a receptor-regulated effector of the TGF-beta signaling cascade, and phosphorylation at threonine 220 marks its activated state during canonical signal transduction. This rabbit polyclonal reagent from Antibodies.com binds specifically to the phospho-T220 epitope, enabling researchers to monitor SMAD2 activation status by Western blot in human cell and tissue lysates. The unconjugated IgG formulation allows flexible pairing with custom secondary detection chemistries, including HRP- or fluorophore-conjugated anti-rabbit reagents, depending on the experimental design. The antibody is supplied in a 50 µl vial format suited to multiple blot experiments when diluted according to standard immunoblotting protocols. Phospho-SMAD2 detection supports investigation of TGF-beta-driven processes including epithelial-mesenchymal transition, fibrotic remodeling, cytokine response, and tumor suppressor pathway activity, making this reagent useful in cell signaling, cancer biology, and inflammation research workflows.