Anti-Smad2 (Ab-220) Antibody

Investigators studying canonical TGF-β signal transduction rely on this rabbit polyclonal reagent from Antibodies.com to monitor Smad2, the receptor-regulated Smad that translocates to the nucleus after type I receptor-mediated phosphorylation. The antibody is raised against a conserved epitope on Smad2 and validated for western blot and immunohistochemistry across human, mouse, and rat samples, supporting cross-species comparison in signaling studies. Provided as 50 µl of unconjugated antiserum, it is suited to immunoblot detection of total or phospho-Smad2 and to chromogenic or fluorescent IHC on formalin-fixed paraffin-embedded sections, enabling investigation of epithelial-mesenchymal transition, fibrotic remodeling, and tumor-microenvironment biology where canonical TGF-β readouts are required. Each preparation is affinity-purified and quality-controlled by western blot, delivering reproducible results across runs and blots.