Anti-Smad1 (Ab-187) Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com recognizes Smad1, a receptor-regulated Smad protein that transduces signals from activated bone morphogenetic protein (BMP) type I receptors into the nucleus. Smad1 partners with the common-mediator Smad4 and binds SMAD-binding elements to drive transcription of BMP-responsive genes involved in osteoblast differentiation, chondrogenesis, dorsal-ventral patterning, and stem cell lineage commitment.

Supplied at 100 µl in an unconjugated format, the reagent is validated for Western blot, immunohistochemistry, and immunofluorescence assays on human samples. The polyclonal host response provides multi-epitope recognition, which can be advantageous when a target is subject to alternative splicing or post-translational modification.

The "Ab-187" designation reflects an immunogen sequence drawn from the Smad1 linker region, which connects the N-terminal MH1 DNA-binding domain to the C-terminal MH2 transactivation domain. Researchers working on BMP signaling, bone biology, and developmental pathways use this reagent to monitor total Smad1 protein abundance and subcellular distribution across stimulated and unstimulated conditions.