Anti-SLC6A1 Antibody

This rabbit polyclonal reagent from Antibodies.com recognizes the SLC6A1 gene product, also known as GAT-1 (sodium- and chloride-dependent gamma-aminobutyric acid transporter type 1), the presynaptic membrane protein responsible for reuptake of GABA from the synaptic cleft. Raised in rabbit and supplied unconjugated at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.2, the antiserum is validated for Western blot and immunocytochemistry, with reactivity confirmed against human, mouse, and rat samples. Each vial delivers 100 µl of polyclonal antibody suitable for probing neuronal membrane fractions, transfected cell lines, and primary neuronal cultures. Researchers studying inhibitory neurotransmission, epilepsy-associated SLC6A1 variants linked to myoclonic-atonic epilepsy and autism spectrum disorder, and GABAergic drug pharmacology rely on this reagent for transporter expression and trafficking studies. For daily use, store refrigerated at 4 degrees C; for long-term stability, aliquot and freeze to limit repeated freeze-thaw cycles. The unconjugated format allows flexible pairing with user-selected secondary antibodies, fluorophores, or HRP conjugates.