Anti-SLC6A1 Antibody

Raised in rabbit, this unconjugated polyclonal IgG reagent targets the SLC6A1 transporter, also known as GABA transporter 1 (GAT-1), a sodium- and chloride-dependent carrier responsible for reuptake of the inhibitory neurotransmitter GABA from the synaptic cleft. Antibodies.com supplies this primary antibody in a 100 µl vial format, providing affinity-purified reagent validated for western blot and immunohistochemistry workflows on human, mouse, and rat samples. Endogenous GAT-1 expression is concentrated in the central nervous system, particularly on presynaptic GABAergic neurons and certain astrocytic populations, where the transporter modulates tonic inhibition and shapes network excitability. Researchers studying epilepsy genetics, SLC6A1-linked neurodevelopmental disorders, and inhibitory synapse biology use this reagent to map transporter distribution in brain tissue sections and to confirm expression changes in cell and animal models. The unconjugated format supports flexible detection with secondary antibodies of the researcher's choice, including fluorescent, HRP, or biotin conjugates. For long-term storage, keep the vial at -20 °C in working aliquots to limit freeze-thaw cycles, and avoid prolonged exposure to light when working with fluorophore-conjugated secondaries downstream.