Anti-SLC39A6 Antibody

SLC39A6 is a multi-pass plasma membrane zinc importer belonging to the ZIP transporter family (UniProt Q13433, gene aliases LIV-1, ZIP6, Ermelin) that mediates cellular zinc uptake and contributes to intracellular zinc homeostasis. This primary antibody reagent from Antibodies.com is raised in rabbits and affinity-purified as an unconjugated IgG polyclonal, supplied at 100 µl per vial in PBS buffer containing 50% glycerol and 0.02% sodium azide at pH 7.3, ready for western blot and immunohistochemistry workflows on human, mouse, and rat samples. The polyclonal format provides recognition of multiple epitopes on the target, supporting signal detection in IHC on formalin-fixed paraffin-embedded tissue sections and in western blot analysis of whole-cell lysates. Predicted molecular weight is approximately 49 kDa, with observed bands commonly reported near 85-102 kDa reflecting post-translational modification and glycosylation of the transporter. Recommended storage is at -20°C after aliquoting to avoid repeated freeze-thaw cycles, and the reagent is shipped on cold packs. SLC39A6 has been characterized as an estrogen-induced transcript whose elevated expression has been associated with lymph node involvement in hormone receptor-positive breast cancer, and the protein has been implicated in epithelial-mesenchymal transition as well as neural crest cell migration during early morphogenesis, making this antibody useful for profiling ZIP transporter expression, characterizing zinc uptake mechanisms, and screening tumor markers in oncology and developmental biology research. For research use only.