Anti-SLC34A1 Antibody

SLC34A1 encodes the type IIa sodium-phosphate cotransporter (NaPi-IIa), a renal brush-border membrane protein central to inorganic phosphate reabsorption and systemic mineral homeostasis. This rabbit polyclonal reagent from Antibodies.com is raised against the human SLC34A1 sequence and validated for Western blot and immunohistochemistry workflows across human, mouse, and rat sample types, supporting studies of kidney tubule physiology, bone-mineral metabolism, and chronic kidney disease models.

The antibody is supplied as 100 µl of unconjugated liquid at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant. Short-term storage at 4°C is acceptable; for longer intervals the vial should be aliquoted and held at -20°C to limit freeze-thaw exposure. The polyclonal format targets multiple epitopes on the NaPi-IIa cytoplasmic and transmembrane regions, which is useful when probing samples where post-translational regulation of the transporter (membrane retrieval, ubiquitination, PTH-driven internalization) is itself the experimental question.

Because endogenous SLC34A1 expression is largely restricted to the renal proximal tubule, the reagent pairs well with segment-specific markers such as AQP1 or megalin in double-labeling studies of nephron function, and it can be combined with HRP-, biotin-, or fluorophore-conjugated secondaries in indirect detection protocols.