Anti-SLC25A4 Antibody

This polyclonal antibody from Antibodies.com targets SLC25A4 (also called ANT1 or Adenine Nucleotide Translocator 1), an integral inner mitochondrial membrane protein that catalyzes the exchange of matrix ATP for cytoplasmic ADP, a process essential for oxidative phosphorylation and cellular bioenergetics. Raised in rabbit and supplied unconjugated at 100 µl, the reagent is validated for Western blot analysis of cell and tissue lysates as well as immunohistochemistry on fixed sections, with demonstrated reactivity across human, mouse, and rat samples.

Because SLC25A4 sits at the crossroads of mitochondrial ADP/ATP flux, the antibody supports investigations into disorders where this exchange is disrupted, including autosomal dominant progressive external ophthalmoplegia, mitochondrial myopathy, and hypertrophic cardiomyopathy. Researchers studying cardiac or skeletal muscle biology, metabolic disease, or mitochondrial dysfunction can use the reagent to track endogenous protein expression, isoform-specific localization patterns, and changes in translocator abundance under different physiological or stress conditions. The polyclonal format broadens epitope coverage, which can help in detecting conformational or post-translationally modified forms of the transporter.