Anti-SLC22A8 Antibody

Raised in rabbit, this polyclonal antibody recognizes the SLC22A8 transporter, also widely cited in the literature as OAT3 (organic anion transporter 3), a multi-pass membrane protein best known for mediating basolateral uptake of organic anions in renal proximal tubule cells and for clearing drugs, metabolites, and signaling molecules across the blood-brain barrier. The unconjugated reagent is supplied by Antibodies.com as a 100 µl volume and is validated for western blot analysis of endogenous SLC22A8 in human, mouse, and rat samples, as well as for immunohistochemistry applications that localize transporter expression in kidney cortex, choroid plexus, and brain microvasculature. Researchers studying renal organic anion clearance, blood-brain barrier transport, nephrotoxicity, or pharmacokinetic drug-drug interactions with OAT3 substrates commonly deploy this reagent to probe transporter abundance and tissue distribution, frequently alongside uptake assays, inhibitor studies on polarized epithelial models, or transporter knockdown experiments. The polyclonal format increases the likelihood of recognizing multiple epitopes on the membrane protein, which can be advantageous when working with samples in which a single linear epitope may be masked by post-translational modification or partial denaturation during lysate preparation.