Anti-SLC22A2 Antibody

Solute Carrier Family 22 Member A2 (SLC22A2), commonly called the organic cation transporter 2 (OCT2), is a 12-transmembrane plasma membrane protein best known for clearing endogenous cations and many cationic drugs across renal proximal tubules and for modulating cholinergic signaling in the central nervous system. The Antibodies.com Anti-SLC22A2 polyclonal reagent is a rabbit host, unconjugated antibody validated for Western blot detection of the transporter across human, mouse, and rat samples. At 1 mg/mL in PBS with 0.1% sodium azide and 50% glycerol, the 100 µL vial ships as a concentrated stock that can be diluted directly into standard Laemmli sample buffer and probed with HRP-linked goat anti-rabbit secondary reagents for chemiluminescent imaging on nitrocellulose or PVDF membranes. Because the antibody is polyclonal, it recognizes several epitopes spread across the intracellular and extracellular loops of OCT2, an advantage when probing transporter glycoforms or low-abundance endogenous transporter in primary tissue lysates. Researchers studying renal drug clearance, metformin uptake, platinum-based chemotherapeutic handling, or organic cation flux in neurodegenerative models routinely apply this reagent to compare transporter abundance between cell-line models and clinical biopsy specimens. The 50% glycerol cryobuffer protects the antibody during repeated freeze-thaw cycles across multi-session Western blot campaigns, while 0.1% sodium azide maintains microbial stability during prolonged benchtop use. Cross-species reactivity to human, mouse, and rat protein makes this reagent well suited to translational pipelines that move between cultured cells, primary rodent kidney cortex or brain tissue, and patient-derived material.