Anti-SLC22A17 Antibody

The SLC22A17 protein, also known as 24p3R or NGALR, functions as a cell-surface receptor for lipocalin-2 (LCN2/NGAL) and plays a role in iron uptake, apoptosis regulation, and inflammatory signaling. This unconjugated rabbit polyclonal IgG antibody from Antibodies.com is raised against the SLC22A17 target and is supplied as 50 µL of ready-to-use reagent. It has been validated for western blot (WB) and immunohistochemistry (IHC) workflows and shows reactivity against human, mouse, and rat samples, making it a useful reagent for cross-species studies in renal pathophysiology, cancer research, and neuroinflammation models.

As a primary antibody, the reagent is intended for detection of endogenous SLC22A17 expression in tissue sections and cell lysates. Researchers investigating acute kidney injury, tumor cell survival, or iron-trafficking pathways have used anti-SLC22A17 antibodies to probe the lipocalin-2 receptor axis. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which can improve signal in IHC staining of formalin-fixed paraffin-embedded samples where the target may be partially masked by fixation chemistry.

For western blot, the antibody is applied to membrane-immobilized proteins under standard reduced denaturing conditions, while IHC use benefits from antigen retrieval steps chosen for the specific tissue of interest. Each vial is supplied at a working dilution that supports both chromogenic and fluorescence detection, and the unconjugated format allows researchers to pair it with their preferred secondary antibody and label system, including HRP, biotin, or fluorophore conjugates chosen downstream.