Anti-SLC22A12 Antibody

This rabbit polyclonal antibody targets SLC22A12, the gene encoding URAT1 (urate transporter 1), a membrane protein localized to the apical brush border of renal proximal tubule cells where it mediates urate reabsorption from primary urine. The unconjugated reagent is raised in rabbit and validated for Western blot and immunohistochemistry on human samples, making it a useful tool from Antibodies.com for investigators studying renal urate handling, idiopathic renal hypouricemia, and the contribution of SLC22A12 variants to gout susceptibility and serum urate homeostasis.

Provided as a 100 µL liquid aliquot of polyclonal IgG, the antibody is suitable for standard immunoblotting workflows and chromogenic IHC on fixed tissue sections. Because SLC22A12 expression is enriched in the kidney cortex and modulated by drugs such as probenecid, losartan, and pyrazinamide, researchers frequently use this reagent to examine transporter abundance under drug treatment, in disease models, or in patient-derived biopsy material.